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GF02 - Chemical sensor, bio-sensors and bio-interfaces

Motivations
Graphene and related materials (GRMs) are highly sensitive to the interaction with molecules, making them ideal candidates for chemical sensing, allowing in principle single molecule detection. The efficiency of charge transfer is also very sensitive to the magnetic moment of the molecules, giving another degree of freedom for detection. Future advances include the development of new devices to interface sensors to biological systems, from single live cells to tissues. Graphene’s low electrical noise and easy integration with flexible technology is promising for applications in neural prostheses. The combination of novel sensing technologies (electrical, electrochemical, optical) and biology could enable sub-cellular resolution of cell-surface potential dynamics, and lead to new devices.

This call topic targets the exploitation and development of novel technologies based on GRMs related to health applications, by exploring high-risk research directions with convergence of science and cutting-edge engineering.
Complementarities are envisaged with WP7(Sensors), WP2(Health&Environment), WP8(Flexible Electronics), WP1(Materials). Consortia are required to have at least one industrial partner.

Objectives

  • Selective detection of single molecules, either in gas or aqueous phase. Complex molecules such as proteins, enzymes or peptides and even 2d-supramolecular layers can be considered as sensitive physisorbed layers.
  • Cell-bionic systems. Technologies and strategies for bidirectional communication with living cells and biological tissue, aiming at cellular and subcellular resolution. These might be based on electrical, chemical, or optoelectrochemical communications, and should be able to report biological cell generated changes in the membrane surface potential, but also on chemical signals (neurotransmitters, ions, etc.) involved in cell communication
  • Detection of electric field and chemical gradients at the membrane/cell surface. Time lapse images of surface potential changes or release of neurotransmitters.
  • Development of multidirectional interfacing, e.g. therapeutic interfaces, such as neural prostheses, providing solutions to the challenges of mechanical mismatch between electronic devices and soft biological tissue.

Impact

  • Market penetration of GRMs as sensors-inspiring components
  • Innovative concepts in bionic systems
  • Translation of basic discoveries into manufacturing products for clinical, environmental, or defence needs.

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